The fate of triphenyllead acetate in the rat
| Autor: | R. Tecwyn Williams, L. Graham Dring, Barbara Williams |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Phenylsulfate
medicine.medical_treatment Intraperitoneal injection Administration Oral Urine Toxicology Expired air Drug Stability Terphenyl Compounds Oral route medicine Organometallic Compounds Animals Tissue Distribution Cysteine Feces Pharmacology Chromatography Chemistry Triphenyllead acetate Hydrogen-Ion Concentration Rats Lead Toxicity Female Digestive System Injections Intraperitoneal |
| Zdroj: | Toxicology and applied pharmacology. 46(3) |
| ISSN: | 0041-008X |
| Popis: | Triphenyllead acetate labeled with 14C or 3H in the benzene rings or with 203Pb has been synthesized and its fate in the rat has been partially elucidated. The compound is about 30 to 50 times more toxic to rats intraperitoneally than orally. Given orally (25 or 200 mg/kg) or intraperitoneally (2 mg/kg) most of the lead is excreted in the feces (up to 76% in 7 days). Sixty-five to eighty percent of the label of orally administered tri[14C]phenyllead acetate (25 mg/kg) is eliminated in 6 days, with 26, 27, or 21% occurring in the urine, feces, and expired air, respectively. The 14C in the urine was partially identified as quinol monosulfate (2%) and phenylsulfate (13%), that of the feces as unchanged triphenyllead acetate (4.5%), and that of the expired air as benzene (20%) and CO2 (1%). After an intraperitoneal injection of tri[3H]phenyllead acetate (2 mg/kg), 77% of the 3H was eliminated in 14 days, with 20, 51, and 7% being in the urine, feces, and expired air, respectively. The 14C in the urine collected after 3 days contained quinol monosulfate ( |
| Databáze: | OpenAIRE |
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