Mathematical Modelling of COVID-19 Transmission in Kenya: A Model with Reinfection Transmission Mechanism
| Autor: | Winnie Kaluki, Virginia Kitetu, Mary Wainaina, Stanley Sewe, Isaac Mwangi Wangari, George Kimathi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19) Databases Factual Article Subject Physical Distancing Computer applications to medicine. Medical informatics Psychological intervention R858-859.7 Asymptomatic Models Biological General Biochemistry Genetics and Molecular Biology Intensive care Pandemic medicine Humans Computer Simulation Intensive care medicine Asymptomatic Infections Pandemics General Immunology and Microbiology Transmission (medicine) business.industry Mechanism (biology) SARS-CoV-2 Applied Mathematics Masks COVID-19 Computational Biology General Medicine Kenya Modeling and Simulation Reinfection Disease Susceptibility medicine.symptom Contact Tracing business Contact tracing Research Article |
| Zdroj: | Computational and Mathematical Methods in Medicine, Vol 2021 (2021) Computational and Mathematical Methods in Medicine |
| ISSN: | 1748-6718 |
| Popis: | In this study we propose a Coronavirus Disease 2019 (COVID-19) mathematical model that stratifies infectious subpopulations into: infectious asymptomatic individuals, symptomatic infectious individuals who manifest mild symptoms and symptomatic individuals with severe symptoms. In light of the recent revelation that reinfection by COVID-19 is possible, the proposed model attempt to investigate how reinfection with COVID-19 will alter the future dynamics of the recent unfolding pandemic. Fitting the mathematical model on the Kenya COVID-19 dataset, model parameter values were obtained and used to conduct numerical simulations. Numerical results suggest that reinfection of recovered individuals who have lost their protective immunity will create a large pool of asymptomatic infectious individuals which will ultimately increase symptomatic individuals with mild symptoms and symptomatic individuals with severe symptoms (critically ill) needing urgent medical attention. The model suggests that reinfection with COVID-19 will lead to an increase in cumulative reported deaths. Comparison of the impact of non pharmaceutical interventions on curbing COVID19 proliferation suggests that wearing face masks profoundly reduce COVID-19 prevalence than maintaining social/physical distance. Further, numerical findings reveal that increasing detection rate of asymptomatic cases via contact tracing, testing and isolating them can drastically reduce COVID-19 surge, in particular individuals who are critically ill and require admission into intensive care. |
| Databáze: | OpenAIRE |
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