Analysis of the Effects of Fentanyl in the Feline Pulmonary Vascular Bed
| Autor: | Shane Huffman, Amir Baluch, James Phelps, Ikhlass N. Ibrahim, Jason M. Hoover, Aaron M. Fields, Alan D. Kaye |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Pulmonary Circulation
medicine.drug_class Narcotic Antagonists Vasodilator Agents Blood Pressure (+)-Naloxone Pulmonary Artery Pharmacology Bradykinin Nitric Oxide Fentanyl Norepinephrine Histamine receptor Animals Medicine Pharmacology (medical) Dose-Response Relationship Drug Naloxone business.industry Diphenhydramine Histaminergic General Medicine medicine.disease Receptor antagonist Pulmonary hypertension Analgesics Opioid Vasodilation Opioid Cyclooxygenase 2 Receptors Opioid Cats Histamine H1 Antagonists business Histamine medicine.drug |
| Zdroj: | American Journal of Therapeutics. 13:478-484 |
| ISSN: | 1075-2765 |
| DOI: | 10.1097/01.mjt.0000178338.43545.3a |
| Popis: | The objective of this study was to test the hypothesis that fentanyl induces a depressor response in the pulmonary vascular bed of the cat and to identify the receptors involved in the mediation or modulation of these effects. The authors conducted a prospective vehicle-controlled study at a university research laboratory using intact chest preparation in adult mongrel cats. In separate experiments, the effects of diphenhydramine (histamine receptor blocker), glibenclamide (ATP-sensitive K+ channel blocker), L-N5-(1-Iminoethyl) ornithine hydrochloride (L-NIO) (nitric oxide synthase inhibitor), nimesulide (selective cyclooxygenase [COX]-2 inhibitor), and naloxone (opiate receptor antagonist) were investigated on pulmonary arterial responses to fentanyl and other agonists in the pulmonary vascular bed of the cat. The systemic pressure and lobar arterial perfusion pressure were continuously monitored, electronically averaged, and recorded. In the feline pulmonary vascular bed of the isolated left lower lobe, fentanyl induced a dose-dependent vasodepressor response that was not significantly altered after administration of glibenclamide, L-NIO, and nimesulide. However, the responses to fentanyl were significantly attenuated after administration of diphenhydramine and naloxone. The results of the present study suggest that fentanyl has potent vasodepressor activity in the pulmonary vascular bed of the cat and that this response may be mediated or modulated by both histaminergic and opiate receptor sensitive pathways. |
| Databáze: | OpenAIRE |
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