Efficacy and safety of autologous platelet-rich fibrin for the treatment of infertility with intrauterine adhesions
| Autor: | Mukun Yang, Lei Cui, Zijun Wang, Zhaoxi Hou, Wenpei Bai, Xiao‐xue Wang, Lele Mao, Guang-Xia Cui, Min Yang, Shuowen Wang |
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| Rok vydání: | 2021 |
| Předmět: |
Infertility
medicine.medical_specialty media_common.quotation_subject Placenta Adhesion (medicine) Tissue Adhesions Hysteroscopy Menstruation Pregnancy Platelet-Rich Fibrin medicine Humans Prospective Studies Menstrual cycle media_common Uterine Diseases medicine.diagnostic_test business.industry Obstetrics and Gynecology medicine.disease digestive system diseases Surgery Pregnancy rate medicine.anatomical_structure Female Uterine cavity business |
| Zdroj: | The journal of obstetrics and gynaecology researchReferences. 47(11) |
| ISSN: | 1447-0756 |
| Popis: | Aim To evaluate the efficacy and safety of autologous platelet-rich fibrin (PRF) for the treatment of infertility with intrauterine adhesions. Methods Forty patients who suffered from infertility with intrauterine adhesions (IUAs) were enrolled in this prospective trial from October 2018 to December 2019. They were randomly divided into a PRF group and a control group. Both groups underwent transcervical resection of adhesions (TCRA) during the follicular phase. PRF group: PRF prepared from autologous venous blood was placed in the uterine cavity after TCRA and after the first menstrual re-fluid; control group: no PRF insertion. After the second menstrual re-fluid, both groups underwent hysteroscopy to reevaluate adhesion severity. Pregnancy rate, intrauterine adhesion score, menstrual volume and duration, and endometrial thickness were assessed and adverse events were recorded. Results (1) PRF group pregnancy rate was significantly higher than the control group (55.0% vs. 20.0%). Mean follow-up time was (17.63 ± 2.33) months. All patients fell pregnant naturally. Four (PRF) and one (control) patients delivered live births without placental complications. (2) Intrauterine adhesion scores decreased compared with treatment-before. (3) In the pictorial blood loss assessment chart, score and menstrual duration during the 3rd menstrual cycle showed significant improvements for both groups. (4) Endometrial thickness also showed an increasing trend, and subendometrial bloodflow improved. (5) No treatment-related serious adverse events were noted. Conclusion Placing PRF into the uterine cavity of infertility patients with IUAs following TCRA is a safe and effective therapeutic method. |
| Databáze: | OpenAIRE |
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