Ginsenoside-Rb1 Improved Diabetic Cardiomyopathy through Regulating Calcium Signaling by Alleviating Protein O-GlcNAcylation
| Autor: | Xiao Zhang, Linhui Qin, RongRong Zhao, Jianping Wang, Yingwu Mei |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Male Ginsenosides Diabetic Cardiomyopathies Acylation Pharmacology 01 natural sciences Ryanodine receptor 2 Sarcoplasmic Reticulum Calcium-Transporting ATPases Mice Diabetic cardiomyopathy Diabetes mellitus Ca2+/calmodulin-dependent protein kinase medicine Myocyte Animals Humans Myocytes Cardiac Calcium Signaling Calcium signaling Calcium metabolism Chemistry 010401 analytical chemistry Proteins General Chemistry medicine.disease eye diseases 0104 chemical sciences Metformin Mice Inbred C57BL Calcium General Agricultural and Biological Sciences 010606 plant biology & botany medicine.drug |
| Zdroj: | Journal of agricultural and food chemistry. 67(51) |
| ISSN: | 1520-5118 |
| Popis: | Ginsenoside-Rb1 (Rb1), a major active component of ginseng, has many benefits for cardiovascular disease and diabetes mellitus (DM), but the effect and mechanism on diabetic cardiomyopathy are not clear. In the present study, we found that Rb1-feeding significantly improved cardiac dysfunction and abnormal cardiomyocytes calcium signaling caused by diabetes. This improved calcium signaling was because Rb1 reduced Ca2+ leakage caused by overactivated ryanodine receptor 2 (RyR2) and increased Ca2+ uptake by sarcoplasmic reticulum Ca2+-ATPase 2a (SERCA 2a). Furthermore, we found that Rb1 not only enhanced energy metabolism like metformin and eliminated O-GlcNAcylation of calcium handling proteins to regulate calcium signaling but also directly inhibited RyR2 activity to regulate calcium signaling. The present study indicated that as a health supplement or drug, Rb1 was a relatively effective auxiliary therapeutic substance for diabetic cardiomyopathy. |
| Databáze: | OpenAIRE |
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