Characteristic Changes in Heart Rate Variability Indices during Hemorrhagic Shock, and Effect of Liposome-Encapsulated Hemoglobin in Rats
| Autor: | Manabu Kinoshita, Tadaaki Maehara, Yashiro Nogami, Satoshi Shono, Shinichi Kaneda, Masayuki Ishihara, Makoto Kikuchi, Bonpei Takase |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Resuscitation endocrine system lcsh:Diseases of the circulatory (Cardiovascular) system medicine.medical_treatment Blood volume Internal medicine medicine Heart rate variability Autonomic nervous system Saline business.industry Bleeding Albumin Red blood cell medicine.anatomical_structure Endocrinology lcsh:RC666-701 Anesthesia Hemoglobin Volume expander Cardiology and Cardiovascular Medicine business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Arrhythmia, Vol 26, Iss 3, Pp 189-198 (2010) |
| ISSN: | 1880-4276 |
| DOI: | 10.1016/s1880-4276(10)80006-7 |
| Popis: | Many compensatory mechanisms exit in hemorrhagic shock (HS). To characterize the efficacy of the new artificial oxygen carrier, liposome-encapsulated hemoglobin (LHb), HS was induced by withdrawing 20% of the total blood volume from rats. Rats received one of five interventions: LHb resuscitation (LHb-G, n = 7), normal saline (Saline-G, n = 7), shed autologous blood (SAB-G, n = 7), volume expander of 5% albumin (Albumin-G, n = 7), or no treatment (Sham-G, n = 7). Heart rate variability (HRV) indices were measured, including low frequency (LF, 0.10–0.60 Hz), high frequency (HF, 0.60–2.00 Hz), and the ratio of LF to HF (LF/HF). LF and LF/HF following HS were lower in the LHb-G and SAB-G groups when compared with the Saline-G, Albumin-G and Sham-G groups. LF and LF/HF following HS in the LHb-G group were comparable with that of the SAB-G group. These data demonstrate that HS-induced changes can be attenuated by resuscitation with LHb as well as SAB. LHb could be used as a substitute for blood transfusion for HS. |
| Databáze: | OpenAIRE |
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