Regioselective synthesis of 3-benzyl substituted pyrimidino chromen-2-ones and evaluation of anti-microbial and anti-biofilm activities
| Autor: | Narender Reddy Emmadi, Ganesh Kumar Chityal, Narender Reddy Godumagadda, Krishnaiah Atmakur, Jagadeesh Babu Nanubolu, Chiranjeevi Bingi |
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| Rok vydání: | 2014 |
| Předmět: |
Staphylococcus aureus
Clinical Biochemistry Drug Evaluation Preclinical Pharmaceutical Science Microbial Sensitivity Tests Bacillus subtilis medicine.disease_cause Biochemistry Structure-Activity Relationship Acetic acid chemistry.chemical_compound Anti-Infective Agents Ciprofloxacin Drug Discovery medicine Benzopyrans Molecular Biology biology Chemistry fungi Organic Chemistry Regioselectivity Stereoisomerism Antimicrobial biology.organism_classification Micrococcus luteus Pyrimidines Biofilms Molecular Medicine Anti biofilm Nuclear chemistry medicine.drug |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 24:485-489 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2013.12.038 |
| Popis: | Regioselective synthesis of a number of highly functionalized 3-benzylpyrimidino chromen-2-ones (4) were accomplished in a one pot three component reaction in acetic acid and determined their anti-microbial and anti-biofilm activities. Compounds 4o and 4p showed an excellent anti-microbial activity against Micrococcus luteus MTCC 2470 at a par with standard control (Ciprofloxacin) and exhibited best activity against Staphylococcus aureus MTCC 96 and Bacillus subtilis MTCC 121. Further, compounds 4h, 4i, 4m, 4n and 4q showed promising activity against Micrococcus luteus MTCC 2470, Staphylococcus aureus MTCC 96 and Bacillus subtilis MTCC 121. Whereas, compounds 4m showed very promising biofilm inhibition activity against Staphylococcus aureus MLS 16 MTCC 2940 and 4o, 4p showed very potent activity against Staphylococcus aureus MTCC 96 at a par with Ciprofloxacin used as standard control. |
| Databáze: | OpenAIRE |
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