Enhancement of generation of monocyte tissue thromboplastin by bacterial phagocytosis: possible pathway for fibrin formation on infected vegetations in bacterial endocarditis
| Autor: | L Thörig, C.J.W. van Ginkel, J. Thompson, W.G. van Aken, J.I.H. Oh |
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| Rok vydání: | 1979 |
| Předmět: |
Staphylococcus
Phagocytosis Immunology In Vitro Techniques medicine.disease_cause Microbiology Monocytes Fibrin Thromboplastin Tissue factor Staphylococcus epidermidis medicine Animals Humans biology Streptococcus Monocyte Endocarditis Bacterial biology.organism_classification Infectious Diseases medicine.anatomical_structure Protein Biosynthesis biology.protein Parasitology Rabbits Streptococcus sanguis Bacteria circulatory and respiratory physiology Research Article |
| Zdroj: | Infection and Immunity. 25:388-395 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.25.1.388-395.1979 |
| Popis: | The deposition of fibrin on infected vegetations and the presence of mononuclear phagocytes that have phagocytized bacteria are remarkabe features in experimental bacterial endocarditis. In a study in vitro, we show that phagocytosis of bacteria by human monocytes enhances thromboplastin generation by these cells. Maximal enhancement of the generation of thromboplastin by monocytes was about six times compared with that in the control experiment without bacteria, and it was obtained by preincubation of the monocytes with 5 to 10 bacteria per monocyte. No quantitative difference was observed between Staphylococcus epidermidis and Streptococcus sanguis as to the enhancement of the monocyte thromboplastin generation. An enhancement of the procoagulant activity generation was also observed after addition of bacteria to human or rabbit whole blood. Probably, this generation was also due to synthesis of thromboplastin by monocytes. It is conceivable that fibrin deposition on infected vegetations during bacterial endocarditis is mediated by thromboplastin synthesis by monocytes. |
| Databáze: | OpenAIRE |
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