Network analysis reveals crosstalk between autophagy genes and disease genes
| Autor: | Ji-Ye Wang, Jian-Bing Wu, Yi-lei Fan, Yun Wang, Wei-Xuan Yao |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Disease gene Multidisciplinary Autophagy Computational Biology Computational biology Disease Biology Article 03 medical and health sciences Crosstalk (biology) 030104 developmental biology 0302 clinical medicine Hematological Diseases Cytoplasm Neoplasms 030220 oncology & carcinogenesis Humans Protein Interaction Maps Lysosomes Gene |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep44391 |
| Popis: | Autophagy is a protective and life-sustaining process in which cytoplasmic components are packaged into double-membrane vesicles and targeted to lysosomes for degradation. Accumulating evidence supports that autophagy is associated with several pathological conditions. However, research on the functional cross-links between autophagy and disease genes remains in its early stages. In this study, we constructed a disease-autophagy network (DAN) by integrating known disease genes, known autophagy genes and protein-protein interactions (PPI). Dissecting the topological properties of the DAN suggested that nodes that both autophagy and disease genes (inter-genes), are topologically important in the DAN structure. Next, a core network from the DAN was extracted to analyze the functional links between disease and autophagy genes. The genes in the core network were significantly enriched in multiple disease-related pathways, suggesting that autophagy genes may function in various disease processes. Of 17 disease classes, 11 significantly overlapped with autophagy genes, including cancer diseases, metabolic diseases and hematological diseases, a finding that is supported by the literatures. We also found that autophagy genes have a bridging role in the connections between pairs of disease classes. Altogether, our study provides a better understanding of the molecular mechanisms underlying human diseases and the autophagy process. |
| Databáze: | OpenAIRE |
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