Prediction of Arteriovenous Fistula Clinical Maturation from Postoperative Ultrasound Measurements: Findings from the Hemodialysis Fistula Maturation Study
| Autor: | Michelle L, Robbin, Tom, Greene, Michael, Allon, Laura M, Dember, Peter B, Imrey, Alfred K, Cheung, Jonathan, Himmelfarb, Thomas S, Huber, James S, Kaufman, Milena K, Radeva, Prabir, Roy-Chaudhury, Yan-Ting, Shiu, Miguel A, Vazquez, Heidi R, Umphrey, Lauren, Alexander, Carl, Abts, Gerald J, Beck, John W, Kusek, Harold I, Feldman, R, Star |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Time Factors Brachial Artery medicine.medical_treatment Fistula 030232 urology & nephrology Arteriovenous fistula 030204 cardiovascular system & hematology Cohort Studies 03 medical and health sciences Arteriovenous Shunt Surgical 0302 clinical medicine Predictive Value of Tests Renal Dialysis Internal medicine Humans Medicine Postoperative Period Prospective Studies cardiovascular diseases Vascular Patency Dialysis Aged Ultrasonography Receiver operating characteristic business.industry Ultrasound Models Cardiovascular General Medicine Blood flow Middle Aged Prognosis medicine.disease Stenosis Nephrology Cardiology Female Hemodialysis Erratum business Algorithms Blood Flow Velocity |
| Zdroj: | Journal of the American Society of Nephrology. 29:2735-2744 |
| ISSN: | 1533-3450 1046-6673 |
| DOI: | 10.1681/asn.2017111225 |
| Popis: | Background The utility of early postoperative ultrasound measurements in predicting arteriovenous fistula (AVF) clinical maturation is uncertain. Methods We investigated the relationships of ultrasound parameters with AVF clinical maturation in newly created AVF, measured at 1 day and 2 and 6 weeks, in 602 participants of a multicenter, observational cohort study. A backward elimination algorithm identified ultrasound measurements that independently predicted unassisted and overall AVF maturation. Candidate variables included AVF blood flow, diameter, and depth, upper arm arterial diameter, presence of stenosis, presence of accessory veins, seven case-mix factors (age, sex, black race, AVF location, diabetes, dialysis status, and body mass index), and clinical center. We evaluated the accuracy of the resulting models for clinical prediction. Results At each ultrasound measurement time, AVF blood flow, diameter, and depth each predicted in a statistically significant manner both unassisted and overall clinical maturation. Moreover, neither the remaining ultrasound parameters nor case-mix factors were associated with clinical AVF maturation after accounting for blood flow, diameter, and depth, although maturation probabilities differed among clinical centers before and after accounting for these parameters. The crossvalidated area under the receiver operating characteristic curve for models constructed using these three ultrasound parameters was 0.69, 0.74, and 0.79 at 1 day and 2 and 6 weeks, respectively, for unassisted AVF clinical maturation and 0.69, 0.71, and 0.76, respectively, for overall AVF maturation. Conclusions AVF blood flow, diameter, and depth moderately predicted unassisted and overall AVF clinical maturation. The other factors considered did not further improve AVF maturation prediction. |
| Databáze: | OpenAIRE |
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