A C. elegans Myc-like network cooperates with semaphorin and Wnt signaling pathways to control cell migration
| Autor: | Christopher L. Pickett, Donald E. Ayer, Kevin T. Breen |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Transcriptional Activation Plexin Molecular Sequence Data Myc Semaphorins DNA-binding protein Article Animals Genetically Modified Mondo Wnt 03 medical and health sciences 0302 clinical medicine Semaphorin Cell Movement Animals Cell migration Amino Acid Sequence Caenorhabditis elegans Caenorhabditis elegans Proteins Molecular Biology 030304 developmental biology 0303 health sciences ECM biology Cell growth Wnt signaling pathway Gene Expression Regulation Developmental Cell Biology β-catenin biology.organism_classification Cell biology Extracellular Matrix DNA-Binding Proteins Wnt Proteins biology.protein Trans-Activators Signal transduction Dimerization 030217 neurology & neurosurgery Developmental Biology Signal Transduction |
| Zdroj: | Developmental biology. 310(2) |
| ISSN: | 0012-1606 |
| Popis: | Myc and Mondo proteins are key regulators of cell growth, proliferation, and energy metabolism, yet often overlooked is their vital role in cell migration. Complex networks of protein–protein and protein–DNA interactions control the transcriptional activity of Myc and MondoA confounding their functional analysis in higher eukaryotes. Here we report the identification of the transcriptional activation arm of a simplified Myc-like network in Caenorhabditis elegans. This network comprises an Mlx ortholog, named MXL-2 for Max-like 2, and a protein that has sequence features of both Myc and Mondo proteins, named MML-1 for Myc and Mondo-like 1. MML-1/MXL-2 complexes have a primary function in regulating migration of the ray 1 precursor cells in the male tail. MML-1/MXL-2 complexes control expression of ECM components in the non-migratory epidermis, which we propose contributes to the substratum required for migration of the neighboring ray 1 precursor cells. Furthermore, we show that pro-migratory Wnt/β-catenin and semaphorin signaling pathways interact genetically with MML-1/MXL-2 to determine ray 1 position. This first functional analysis of the Myc superfamily in C. elegans suggests that MondoA and Myc may have more predominant roles in cell migration than previously appreciated, and their cooperation with other pro-migratory pathways provides a more integrated view of their role in cell migration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect