Bisbenzylisoquinoline alkaloids inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin
| Autor: | Michinori Akasu, Ken Yasukawa, Mieko Takeuchi, Michio Takido |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Cancer Research
Skin Neoplasms Ratón 9 10-Dimethyl-1 2-benzanthracene Administration Topical Antineoplastic Agents Berbamine Pharmacology medicine.disease_cause 12-O-Tetradecanoylphorbol-13-acetate Benzylisoquinolines chemistry.chemical_compound Mice Alkaloids Oral administration Cepharanthine medicine Animals Anticarcinogenic Agents Stephania Inflammation Mice Inbred ICR Arachidonic Acid biology business.industry Anti-Inflammatory Agents Non-Steroidal General Medicine biology.organism_classification Isoquinolines Oncology chemistry Immunology Tetradecanoylphorbol Acetate Tumor promotion Female Carcinogenesis business |
| Zdroj: | Oncology. 50(2) |
| ISSN: | 0030-2414 |
| Popis: | Bisbenzylisoquinoline alkaloids, cepharanthine, berbamine and isotetrandrine, were isolated from Stephania cepharantha Hayata. These compounds inhibit arachidonic acid-induced inflammation in mice. We have found that cepharanthine inhibits tumor promotion after topical application and oral administration in two-stage carcinogenesis in mouse skin. Furthermore, topical application of berbamine (2 mumol/mouse) and isotetrandrine (2 mumol/mouse) markedly suppressed the tumor-promoting effect of 12-O-tetradecanoylphorbol-13-acetate (1 microgram) in mouse skin initiated with 7,12-dimethylbenz[a]anthracene (50 micrograms), at a grade corresponding to that of cepharanthine. |
| Databáze: | OpenAIRE |
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