Tubular calcium, magnesium, and phosphate excretion during therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy: A prospective study
| Autor: | Doğan Bahadır İnan, Funda Bastug, Ahmet Ozdemir, Osman Baştuğ, Binnaz Celik, Cigdem Karakukcu |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Renal Tubular Transport Inborn Errors Urine Gastroenterology Hypoxic Ischemic Encephalopathy Statistics Nonparametric Hypomagnesemia Phosphates Excretion chemistry.chemical_compound Hyperphosphatemia Hypothermia Induced Internal medicine medicine Humans Magnesium Prospective Studies Hypoxia Brain Creatinine Hypocalcemia business.industry Infant Newborn Hypothermia medicine.disease Perinatal asphyxia chemistry Pediatrics Perinatology and Child Health Calcium Female medicine.symptom business |
| Zdroj: | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. 28(8) |
| ISSN: | 1769-664X |
| Popis: | Hypocalcemia, hypomagnesemia, and hyperphosphatemia are common electrolyte disturbances in perinatal asphyxia (PA). Different reasons have been proposed for these electrolyte disturbances. This study investigated the effect of the urinary excretion of calcium (Ca), magnesium (Mg), and phosphorus (P) on the serum levels of these substances in babies who were treated using therapeutic hypothermia for hypoxic ischemic encephalopathy (HIE) caused by PA. This study sheds light on the pathophysiology that may cause changes in the serum values of these electrolytes.This study included 21 healthy newborns (control group) and 38 patients (HIE group) who had undergone therapeutic hypothermia due to HIE. Only infants with a gestational age of 36 weeks and above and a birth weight of 2000 g and above were evaluated. The urine and serum Ca, Mg, P, and creatinine levels of all infants were evaluated at 24, 48, and 72 h.The lower serum Ca value and the higher serum P value of the HIE group were found to be statistically significant compared to the control group (p0.05). There was no significant difference in serum Mg values between the groups. However, hypomagnesemia was detected in five patients from the HIE group. The urine excretion of FeCa and FeMg at 24 h, and FeP excretion at 48 and 72 h were found to be significantly higher in the HIE group compared to the control group.This study determined that the urinary excretion of Ca, Mg, and P has an effect on the serum Ca, Mg, and P levels of infants with HIE. |
| Databáze: | OpenAIRE |
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