Soy based diet attenuates the development of hypertension when compared to casein based diet in spontaneously hypertensive rat
| Autor: | Riitta Korpela, R Nevala, Jani Vehniäinen, Heikki Vapaatalo, Timo Vaskonen |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty 030309 nutrition & dietetics Blood lipids Blood Pressure 030204 cardiovascular system & hematology General Biochemistry Genetics and Molecular Biology Muscle hypertrophy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Spontaneously hypertensive rat Rats Inbred SHR Internal medicine Casein Animals Medicine Testosterone General Pharmacology Toxicology and Pharmaceutics Soy protein 2. Zero hunger 0303 health sciences Estradiol business.industry Cholesterol Caseins General Medicine Diet Mesenteric Arteries Rats Endocrinology Blood pressure chemistry Hypertension Soybean Proteins Female Hypertrophy Left Ventricular Kidney Diseases business |
| Zdroj: | University of Helsinki |
| ISSN: | 0024-3205 |
| Popis: | The purpose of this study was to compare the effects of soy and casein based diets on blood pressure and cardiovascular functions in male and female spontaneously hypertensive rats (SHR). The systolic blood pressure was measured at the beginning and at the end of study. After a five week supplementation period with three different diets, the rats were decapitated and arterial responses and the weight-to-body weight-ratios of the organs were studied. The development of hypertension was attenuated in both female and male rats on soy protein diet when compared to the casein diet. Soy based diet lowered serum total cholesterol level when compared to the control diet. Both casein and soy protein supplementation in diet induced a significant renal hypertrophy in both female and male SHR rats when compared to SHR rats on the control diet. Soy protein supplementation reduced significantly serum estradiol-17beta concentration when compared to the control diet. There were no differences in the serum testosterone concentrations between the diet groups. When compared to the casein based diet the soy based diet attenuated the development of hypertension and decreased serum total cholesterol level in SHRs. These effects were independent of gender. The mechanisms and clinical importance of these findings remain to be clarified. |
| Databáze: | OpenAIRE |
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