Three newly identified lipophilic flavonoids in Tanacetum parthenium supercritical fluid extract penetrating the Blood-Brain Barrier
| Autor: | András Darcsi, Szabolcs Béni, Eszter Riethmüller, Anita Tóth, Ágnes Alberti, Judit Müller, Krisztina Végh, György T. Balogh, Árpád Könczöl, Levente Hosszú, Ágnes Kéry |
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| Rok vydání: | 2018 |
| Předmět: |
Clinical Biochemistry
Flavonoid Pharmaceutical Science Tanacetum parthenium Sesquiterpene Sesquiterpene lactone 01 natural sciences Analytical Chemistry chemistry.chemical_compound Tandem Mass Spectrometry Drug Discovery Parthenolide Glycosides Chromatography High Pressure Liquid Spectroscopy Flavonoids chemistry.chemical_classification Plants Medicinal Chromatography biology Plant Extracts 010405 organic chemistry Chemistry 010401 analytical chemistry Supercritical fluid extraction Chromatography Supercritical Fluid Asteraceae Flavones biology.organism_classification Lipids Supercritical fluid 0104 chemical sciences Plant Leaves Blood-Brain Barrier |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 149:488-493 |
| ISSN: | 0731-7085 |
| Popis: | Feverfew (Tanacetum parthenium L.) as a perennial herb has been known for centuries due to its medicinal properties. The main sesquiterpene lactone, parthenolide is considered to be responsible for the migraine prophylactic effect, however the pharmacological benefits of the lipophilic flavonoid components can not be neglected. Supercritical fluid extraction (7% ethanol, 22MPa, 64°C) was carried out on the leaves of Tanacetum parthenium L. from which the presence of methylated flavonoids beside parthenolide and other sesquiterpene lactones were indicated by preliminary LC-MS analyses. Specific Parallel Artificial Membrane Permeability Assay (PAMPA) was applied to identify the components capable to cross the Blood-Brain Barrier (BBB). Three lipophilic flavonoids were detected on the acceptor side, that were isolated (Prep-HPLC) and identified as sudachitin, aceronin and nevadensin (LC-MS/MS, NMR). These flavonoids were also characterized individually by PAMPA-BBB model. The presence of sudachitin and nevadensin was proven in the Asteraceae family, but neither of the three flavonoids were reported in Tanacetum parthenium L. |
| Databáze: | OpenAIRE |
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