An IgE-binding TAME esterase in the urine of the mouse, Mus musculus domesticus
| Autor: | L. Berrens |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Urinary system
Immunology Mice Inbred Strains Urine Tripeptide Immunoglobulin E medicine.disease_cause Substrate Specificity Mice Radioallergosorbent Test Allergen Alpha-Globulins Hydrolase medicine Animals Immunology and Allergy chemistry.chemical_classification biology Proteins Kallikrein Enzyme chemistry Biochemistry biology.protein Female Peptide Hydrolases Protein Binding |
| Zdroj: | Immunology Letters. 47:29-32 |
| ISSN: | 0165-2478 |
| DOI: | 10.1016/0165-2478(95)00060-i |
| Popis: | Among the highly heterogeneous components of the mouse urinary protein complex (MUP) a hydrolase was detected which was capable of spliting the proteinase ester substrate TAME as well as a synthetic chromogenic tripeptide specific for tissue and urinary kallikreins. The binding of mouse-specific IgE antibodies from the serum of a highly mouse-allergic patient occurred preferentialy to this kallikrein-like enzyme. This finding underscores the possible association of significant biological activities with predominant IgE-binding allergens, especially in view of the strongly sensitizing potential and the known messenger functions of the MUP proteins. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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