Respiratory rehabilitation in patients recovering from severe acute respiratory syndrome: A systematic review and meta-analysis
| Autor: | Apurba Barman, Mithilesh K Sinha, Jagannatha Sahoo, Debasish Jena, Vikas Patel |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Pulmonary and Respiratory Medicine
COVID-19 Coronavirus disease 2019 DLCO Diffusing capacity of the lung for carbon monoxide Rehabilitation MD Mean difference Vital Capacity EFV1 Forced expiratory volume in 1 s 6-MWD 6-min walking distance Respiratory function tests RR Respiratory rehabilitation ADL Activities of daily living Severe Acute Respiratory Syndrome Critical Care and Intensive Care Medicine Article QoL Quality of life Exercise tolerance FVC Forced vital capacity Quality of Life Humans SARS severe acute respiratory syndrome PFT Pulmonary function test Cardiology and Cardiovascular Medicine Lung |
| Zdroj: | Heart & Lung |
| ISSN: | 0147-9563 |
| DOI: | 10.1016/j.hrtlng.2022.01.005 |
| Popis: | Background With an increase in published reports on respiratory rehabilitation (RR) in severe acute respiratory syndrome (SARS), there is a need for a meta-analysis and systematic review to measure the effects of the RR in SARS. Objective Objective of the review was to evaluate the efficacy and safety of RR in patients recovering from SARS. Methods PubMed/ MEDLINE, CENTRAL, EMBASE, and Clinical Trial Registries were systematically searched (between January 1, 2003, to July 31, 2021) to identify all patients who received RR, at least for six days, following SARS. The primary outcome was exercise capacity [6-meter walking distance (6-MWD)], and secondary outcomes were change in pulmonary function test (PFT) parameters, activities in daily livings (ADLs), and quality of life (QoL). Meta-analysis was performed by using RevMan 5.4. Results Twenty-one observational studies, including eight comparative studies, were included. Eight comparative studies participated in quantitative meta-analysis. The intervention group, who received RR, improved significantly in exercise capacity (6-MWD) [mean difference (MD):45.79, (95% CI:31.66–59.92)] and PFT parameters, especially in forced vital capacity (FVC%) [MD:4.38, (95% CI:0.15–8.60)], and diffusion lung capacity for carbon monoxide (DLCO%) [MD:11.78, (95% CI:5.10–18.46)]. The intervention group failed to demonstrate significant improvement in ADLs and QoL outcomes. No significant adverse events were reported during the intervention. Conclusion Respiratory rehabilitation can improve exercise capacity and PFT parameters in patients recovering from SARS infection. The RR does not cause serious adverse events. Clinical trials to determine the best RR program (in terms of initiation, duration, and components) in SARS and its treatment efficacy, both in the short and long- term are needed. |
| Databáze: | OpenAIRE |
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