Synthesis of 4-Substituted Pyrimidine 2′,3′-Dideoxynucleosides
| Autor: | Daniela Montesarchio, Gennaro Piccialli, L. De Napoli, Anna Messere, Ciro Santacroce |
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| Přispěvatelé: | DE NAPOLI, Lorenzo, A., Messere, Montesarchio, Daniela, Piccialli, Gennaro, C., Santacroce, Denapoli, L, Messere, Anna, Montesarchio, D. |
| Jazyk: | angličtina |
| Rok vydání: | 1991 |
| Předmět: |
Pyrimidine
Bicyclic molecule Dideoxynucleosides Hydrazine NUCLEOSIDE ANALOGUES HUMAN IMMUNODEFICIENCY VIRUS Biochemistry chemistry.chemical_compound chemistry 3'-AZIDO-3'-DEOXYTHYMIDINE CHLORINATION NUCLEOSIDES Genetics Nucleophilic substitution Carbon tetrachloride Organic chemistry BIOACTIVE COMPOUNDS Triphenylphosphine Derivative (chemistry) ORGANIC SYNTHESIS |
| Zdroj: | Scopus-Elsevier |
| Popis: | Reaction of 5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-deoxythymidine with triphenylphosphine/carbon tetrachloride, followed by deprotection of the 5'-hydroxyl group, afforded the 4-chloro derivative 3 from which some 4-substituted pyrimidin-2(1H)one-2',3'-dideoxyribosides were obtained by nucleophilic substitution under very mild conditions. © 1991, Taylor & Francis Group, LLC. All rights reserved. |
| Databáze: | OpenAIRE |
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