Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma
| Autor: | Ludmila Lozneanu, Alex Scripcariu, Irina Draga Căruntu, Elena Corina Andriescu, Elena Roxana Avădănei, Simona Eliza Giuşcă, Cornelia Amălinei, Raluca Balan, Delia Gabriela Ciobanu Apostol |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Pathology medicine.medical_specialty Stromal cell Article Subject Angiogenesis Carcinogenesis lcsh:Medicine Biology Periostin General Biochemistry Genetics and Molecular Biology Metastasis Thyroid carcinoma 03 medical and health sciences Stroma Follicular phase medicine Humans Thyroid Neoplasms Aged Neoplasm Staging General Immunology and Microbiology lcsh:R General Medicine Middle Aged Tumor Pathology medicine.disease Prognosis Carcinoma Papillary Gene Expression Regulation Neoplastic 030104 developmental biology Thyroid Cancer Papillary Female Cell Adhesion Molecules Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2017 (2017) |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Background. Periostin (PN) epithelial and stromal overexpression in tumor pathology has been studied according to tumor growth, angiogenesis, invasiveness, and metastasis, but a limited number of studies address PN in thyroid tumors. Aim. Our study aimed to analyze PN expression in different histological variants of PTC and to correlate its expression with the clinicopathological prognostic factors. Material and Methods. PN expression has been immunohistochemically assessed in 50 cases of PTC (conventional, follicular, oncocytic, macrofollicular, and tall cell variants), in tumor epithelial cells and intratumoral stroma. The association between PN expression and clinicopathological characteristics has been evaluated. Results. Our results show that PTC presented different patterns of PN immunoreaction, stromal PN being significantly associated with advanced tumor stage and extrathyroidal extension. No correlations were found between PN overexpression in tumor epithelial cells and clinicopathological features, except for specific histological variants, the highest risk of poor outcome being registered for the conventional subtype in comparison to the oncocytic type. Conclusions. Our study demonstrates differences in PN expression in histological subtypes of PTC. Our results plead in favor of a dominant protumorigenic role of stromal PN, while the action of epithelial PN is less noticeable. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|