Development of a Solid Formulation Containing a Microemulsion of a Novel Artemisia Extract with Nematocidal Activity for Oral Administration

Autor:	Filip Kiekens, Damián Cordoba-Diaz, Juan José García-Rodríguez, Ines Perez-Roman, Manuel Cordoba-Diaz
Rok vydání:	2020
Předmět:	Benzimidazole Materials science biology Polyvinylpyrrolidone Pharmacology. Therapy tablets lcsh:RS1-441 Pharmaceutical Science silica materials biology.organism_classification lcsh:Pharmacy and materia medica Microcrystalline cellulose chemistry.chemical_compound chemistry D-optimal mixture designs Ultimate tensile strength medicine Artemisia Microemulsion Magnesium stearate solid carrier Powder mixture Nuclear chemistry medicine.drug
Zdroj:	Pharmaceutics, Vol 12, Iss 873, p 873 (2020) Pharmaceutics Volume 12 Issue 9
ISSN:	1999-4923
DOI:	10.3390/pharmaceutics12090873
Popis:	Background: Intestinal nematode infections are usually treated with benzimidazole drugs, but the emergence of resistance to these drugs has led to an increasing demand of new anthelmintic strategies. A new microemulsion formulation (ME) consisting of an Artemisia absinthium extract with proven nematocidal efficacy was previously developed. The aim of our study is to implement a D-optimal mixture design methodology to increase the amount of a silica material (loaded with this ME) in a tablet formulation, considering its tensile strength and disintegration time. Methods: 16 experiments or combinations of the 6 tablet components (loaded silica, microcrystalline cellulose, polyvinylpyrrolidone, croscarmellose, Syloid® 244 FP and magnesium stearate) were assessed. Tensile strength and disintegration time models were developed, and an optimization process was carried out. Results: Tensile strength was improved by increasing the polyvinylpyrrolidone content, while croscarmellose decreased the disintegration time. The optimized powder mixture contains 49.7% w/w of the loaded silica material. A compression force of 12 kN was applied to the powder mixture to form tablets with a tensile strength of 2.0 MPa and a disintegration time of 3.8 min. Conclusions: Our results show that D-optimal mixture designs provide a promising approach to formulate liquid-loaded silica materials.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92452f1506986f4afc199fe0c9e99b5f https://doi.org/10.3390/pharmaceutics12090873 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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