Target Temperature Management and Survival with Favorable Neurological Outcome After Out-of-Hospital Cardiac Arrest in Children: A Nationwide Multicenter Prospective Study in Japan
| Autor: | Satoshi Matsui, Takuro Hayashi, Yasuhiro Ohnishi, Tetsuhisa Kitamura, Hirokazu Takei, Tomohiro Sameshima, Atsushi Hirayama, Ryojiro Tanaka, Tomotaka Sobue, Hiroshi Kurosawa, Go Yoshino, Naoko Tanizawa, Saori Kuratani |
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| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Adolescent business.industry Temperature Odds ratio Return of spontaneous circulation Critical Care and Intensive Care Medicine Logistic regression Cardiopulmonary Resuscitation Confidence interval Anesthesiology and Pain Medicine Japan Hypothermia Induced Internal medicine Propensity score matching Humans Medicine Population study Observational study Prospective Studies Registries Child business Prospective cohort study Out-of-Hospital Cardiac Arrest |
| Zdroj: | Therapeutic Hypothermia and Temperature Management. 12:16-23 |
| ISSN: | 2153-7933 2153-7658 |
| DOI: | 10.1089/ther.2020.0050 |
| Popis: | To assess whether target temperature management (TTM) is effective for 1-month survival with favorable neurological outcome among pediatric patients who achieved return of spontaneous circulation (ROSC) after out-of-hospital cardiac arrest (OHCA). The Japanese Association for Acute Medicine-out-of-hospital cardiac arrest (JAAM-OHCA) Registry, a multicenter prospective observational registry in Japan, included OHCA patients aged ≤17 years who achieved ROSC between June 2014 and December 2017. The primary outcome was 1-month survival with favorable neurological outcomes, defined as pediatric cerebral performance category 1 or 2. We conducted a propensity score analysis with inverse-probability-of-treatment weighting (IPTW) and evaluated the effect of TTM using logistic regression models with IPTW. A total of 167 patients [120 in the non-TTM group (71.9%) and 47 in the TTM group (28.1%)] were eligible for our analysis. The proportion of patients demonstrating 1-month survival with favorable neurological outcomes was 25.5% (12/47) in the TTM group and 16.7% (20/120) in the non-TTM group; there were no significant differences in favorable neurological outcomes (odds ratio, 1.36; 95% confidence interval, 0.55-3.35) between the non-TTM and TTM groups after performing adjustments with IPTW. In our study population composed of pediatric patients who achieved ROSC after OHCA, we did not find a positive association between TTM implementation and 1-month survival with favorable neurological outcomes. |
| Databáze: | OpenAIRE |
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