Elevated levels of circulating heat shock protein 70 (Hsp70) in peripheral and renal vascular disease
| Autor: | El-Nahas Am, J M Corton, Alan Graham Pockley, R. F. M. Wood, B H Wright |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Arbitrary unit Renal Artery Obstruction Immunoenzyme Techniques Heat shock protein Internal medicine medicine Humans HSP70 Heat-Shock Proteins Aged Autoantibodies Autoimmune disease Aged 80 and over Peripheral Vascular Diseases biology Vascular disease business.industry Chaperonin 60 Middle Aged medicine.disease Hsp70 Endocrinology Data Interpretation Statistical Immunology biology.protein HSP60 Female Antibody Cardiology and Cardiovascular Medicine business Intracellular |
| Zdroj: | Heart and vessels. 15(1) |
| ISSN: | 0910-8327 |
| Popis: | Heat shock proteins (Hsp) are families of phylogenetically conserved molecules that have a range of cytoprotective and intracellular functional roles. Reactivity to heat shock proteins has been implicated in the development of autoimmune disease and tissue expression of heat shock proteins and increased levels of anti-Hsp antibodies have also been reported in vascular disease. This study compared circulating levels of Hsp60 and Hsp70 and antihuman Hsp60, antihuman Hsp70, and antimycobacterial Hsp65 antibodies in peripheral (PVD) and renal (RVD) vascular disease with those in age- and sex-matched controls. Levels of Hsp70 were higher in both PVD (median 580 vs 40; P < 0.01) and RVD (median 160 vs 0; P < 0.03), whereas there were no differences in Hsp60 levels. Anti-Hsp60 antibody levels were elevated in PVD (146 vs 81 arbitrary units/ml; P < 0.04), but not RVD. This is the first study to demonstrate increased levels of circulating Hsp70 in pathological disease states; however, its physiological role remains to be determined. |
| Databáze: | OpenAIRE |
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