Protective effects of duloxetine against chronic immobilisation stress-induced anxiety, depression, cognitive impairment and neurodegeneration in mice
| Autor: | Anushri Somavarapu, Glory Florence Meejuru, Lakshmi Sudeepthi Nissankara Roa, Ravi Chandra Sekhara Reddy Danduga, Phani Kumar Kola |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pharmaceutical Science Hippocampus Duloxetine Hydrochloride medicine.disease_cause Neuroprotection Antioxidants Superoxide dismutase Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Animals Medicine Duloxetine Memory impairment Cognitive Dysfunction 030304 developmental biology Pharmacology Psychotropic Drugs 0303 health sciences Behavior Animal Dose-Response Relationship Drug biology Superoxide Dismutase business.industry Glutamate receptor Glutathione Catalase Oxidative Stress Neuroprotective Agents Treatment Outcome Endocrinology chemistry Nerve Degeneration biology.protein business Excitatory Amino Acid Antagonists 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Journal of Pharmacy and Pharmacology. 73:522-534 |
| ISSN: | 2042-7158 0022-3573 |
| Popis: | Objectives This study aimed to evaluate the effect of duloxetine (10 and 20 mg/kg) against chronic immobilisation stress (CIS)-induced anxiety, depression, cognitive impairment and neurodegeneration in mice. Methods CIS, 2 h/10 days (11:00 AM–1:00 PM) was applied after 30 min of pretreatment with saline, duloxetine 10 mg/kg and 20 mg/kg to the respective groups of animals, except the control group. Animals were examined for physiological (body weight, locomotion and grip strength), psychological (memory impairment, anxiety and depression), neurochemical (GABA and glutamate), biochemical (MDA, catalase, glutathione, superoxide dismutase) and histopathological changes. Key findings CIS exposure revealed anxiety-like behaviour, depression-like behaviour, motor in-coordination and learning and memory impairment in mice. Besides, CIS induction decreased the antioxidant enzymes (GSH, SOD and catalase), GABA and the viable neuronal cell count, whereas CIS exposure significantly elevated the MDA, AChE activity and glutamate content in the cortex and hippocampus. Pretreatment with duloxetine10 and 20 mg/kg showed dose-dependent ameliorated effect against the CIS-induced alterations in mice. Conclusion In conclusion, the results of this study demonstrated the protective effect of duloxetine against neuropsychiatric symptoms, memory impairment caused by CIS-induction through inhibition of oxidative stress, AChE activity and glutamate release. |
| Databáze: | OpenAIRE |
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