High plasma levels of endothelin-1 enhance the predictive value of preclinical atherosclerosis for future cerebrovascular and cardiovascular events: a 20-year prospective study
| Autor: | Manfredi Rizzo, Angela Sansone, Claudio Pernice, Francesco Paolo Guarneri, Salvatore Novo, Giuseppina Novo |
|---|---|
| Přispěvatelé: | Novo, G, Sansone, A, Rizzo, M, Guarneri, FP, Pernice, C, Novo, S |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Carotid Artery Diseases
Male Predictive Value of Test Carotid Intima-Media Thickness Risk Factors Cardiovascular Disease follow-up Prospective Studies cardiovascular events cerebrovascular events endothelin-1 Adult Aged Asymptomatic Diseases Biomarkers Cardiovascular Diseases Cerebrovascular Disorders Endothelin-1 Female Follow-Up Studies Humans Middle Aged Plaque Atherosclerotic Predictive Value of Tests Prognosis Cardiology and Cardiovascular Medicine Medicine (all) Prospective cohort study Follow up studies General Medicine cardiovascular event Predictive value Predictive value of tests Cerebrovascular Disorder Cardiology Human medicine.medical_specialty Prognosi cerebrovascular event Follow-Up Studie Carotid Intima-Media Thickne Internal medicine medicine Asymptomatic Disease Carotid Artery Disease business.industry Vascular disease Risk Factor Biomarker medicine.disease Endothelin 1 Settore MED/11 - Malattie Dell'Apparato Cardiovascolare Prospective Studie High plasma business |
| Popis: | BACKGROUND AND PURPOSE: Clinical and experimental evidence suggests that endothelin-1 (Et-1) plays a role in cardiac and vascular disease. In the present study, we investigated the prognostic significance of Et-1 for cerebrovascular and cardiovascular outcome, in a 20-year follow-up. METHODS: We studied 82 originally healthy individuals, referred to our Unit of Cardiovascular Prevention, to evaluate the presence of asymptomatic carotid lesions. We subdivided these individuals into two groups, according to the plasma values of Et-1 (respectively ≤ or >2.7 pg/ml). Traditional cardiovascular risk factors were investigated, and by carotid ultrasound examination, we distinguished between normal individuals and those with intima-media thickening or asymptomatic carotid plaque. RESULTS: Major cardiac and cerebral events (all-cause death, myocardial infarction, revascularization procedures, fatal and nonfatal stroke) were registered in 41 individuals and significantly more in those with high vs. low Et-1 levels (95 vs. 5%; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|