Impact of COVID-19 Pandemic on Psychophysical Stress in Patients with Adrenal Insufficiency: The CORTI-COVID Study
| Autor: | Marianna Martino, Giorgio Arnaldi, Marco Cola, Alessandro Ciarloni, Gianmaria Salvio, Nairus Aboud, Giulia Giancola |
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| Rok vydání: | 2020 |
| Předmět: |
Male
AddiQoL Pediatrics Endocrinology Diabetes and Metabolism Emotions Physiology Hypopituitarism Endocrinology Pandemic Prevalence Global health Medicine Aged 80 and over Adrenal crisis Middle Aged Telemedicine Italy Quarantine Cohort Female Original Article Telemedicine COVID medicine.symptom Glucocorticoid medicine.drug Addison Adult medicine.medical_specialty Adolescent Coronavirus disease 2019 (COVID-19) SF-36 Young Adult Adrenal insufficiency Humans In patient Medical history Pandemics Aged SARS-CoV-2 business.industry COVID-19 medicine.disease Cross-Sectional Studies Socioeconomic Factors Quality of Life Life expectancy business Stress Psychological Adrenal Insufficiency Declaration of Helsinki |
| Zdroj: | Journal of Endocrinological Investigation |
| ISSN: | 1556-5068 |
| DOI: | 10.2139/ssrn.3668368 |
| Popis: | Background: COVID-19 is a novel threat to patients with adrenal insufficiency (AI), whose life expectancy and quality (QoL) are impaired by increased risk of infections and stress-triggered adrenal crises (AC). If infected, AI patients require prompt replacement tailoring. We interviewed a cohort of AI patients assessing: COVID-19 prevalence and clinical presentation; prevalence of AC and association with intercurrent COVID-19 or pandemic-related psychophysical stress; lockdown-induced emotional burden, and health-related QoL. Methods: In this monocentric (Ancona University Hospital, Italy), cross-sectional study covering February-April 2020, 121 (40 primary, 81 secondary) AI patients completed telematically the following three questionnaires: purpose-built “CORTI-COVID”, assessing medical history and concern for COVID-19-related global health, AI-specific personal health, occupational, economic, and social consequences; AddiQoL-30; Short-Form-36 (SF-36) Health Survey. Findings: COVID-19 occurred in one (0·8% prevalence) 48-year-old woman with primary AI, who promptly tailored her replacement. Dyspnea lasted three days, without requiring hospitalization. Secondary AI patients were not involved. No AC were experienced, but pandemic-related stress accounted for 6/14 glucocorticoid up-titrations. Mean CORTI-COVID was similar between groups, mainly depending on “personal health” in primary AI (ρ=0·888, p |
| Databáze: | OpenAIRE |
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