Zwitterionic surface coating of quantum dots reduces protein adsorption and cellular uptake
| Autor: | Neus Feliu, Joonhyuck Park, Dakyeon Lee, Sungjee Kim, Junhwa Lee, Alaa Hassan Said, Sumaira Ashraf, Karsten Kantner, Wolfgang J. Parak, Gerd Ulrich Nienhaus, Raimo Hartmann, Pauline Maffre, Mathilde A. Bichelberger |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
media_common.quotation_subject Analytical chemistry Nanoparticle Serum Albumin Human 02 engineering and technology 010402 general chemistry 01 natural sciences HeLa Adsorption Quantum Dots medicine Humans General Materials Science Internalization media_common biology technology industry and agriculture Biological Transport equipment and supplies 021001 nanoscience & nanotechnology Human serum albumin biology.organism_classification 0104 chemical sciences Surface coating Quantum dot Biophysics 0210 nano-technology HeLa Cells Protein adsorption medicine.drug |
| Zdroj: | Nanoscale. 8:17794-17800 |
| ISSN: | 2040-3372 2040-3364 |
| DOI: | 10.1039/c6nr05805a |
| Popis: | We have studied the effect of the zwitterionic surface coating of quantum dots (QDs) on their interaction with a serum supplemented cell medium and their internalization by human cervical carcinoma (HeLa) cells. Zwitterionic QDs showed negligible adsorption of human serum albumin (HSA) selected as a model serum protein, in contrast to similar but negatively charged QDs. The incorporation of zwitterionic QDs by HeLa cells was found to be lower than for negatively charged QDs and for positively charged QDs, for which the uptake yield was largest. Our results suggest that the suppression of protein adsorption, here accomplished by zwitterionic QD surfaces, offers a strategy that allows for reducing the cellular uptake of nanoparticles. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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