In vivo diffusion tensor imaging of chronic spinal cord compression in rat model
| Autor: | Shujuan Fan, Edward S. Hui, Yong Hu, Darrell T.H. Li, Abby Y. Ding, Matthew M. Cheung, Ed X. Wu |
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| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty Diffusion Rats Sprague-Dawley Lesion White matter Myelopathy Spinal cord compression Image Processing Computer-Assisted Animals Medicine Spinal cord injury Brain Mapping medicine.diagnostic_test business.industry Brain Neurodegenerative Diseases Magnetic resonance imaging medicine.disease Spinal cord Rats Diffusion Magnetic Resonance Imaging Diffusion Tensor Imaging medicine.anatomical_structure Spinal Cord nervous system medicine.symptom business Spinal Cord Compression Diffusion MRI |
| Zdroj: | 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. |
| DOI: | 10.1109/iembs.2009.5333389 |
| Popis: | Chronic spinal cord compression induced cervical myelopathy is a comon cause of spinal cord dysfunction. The exact mechanisms of underlying progressive cell death remain to be elucidated. In this study, in vivo diffusion tensor imaging (DTI) has been applied to investigate the microstructural changes of white matter (WM) in this neurodegenerative disease. Compared with conventional MRI techniques, DTI is believed to be more specific to pathological changes. Radial diffusivity (lambda upper left and right quadrants) is higher in the ipilesional region, suggesting demyelination or axonal degradation may occur after prolonged compression. Near the epicenter of lesion, axial diffusivity (lambda(//)) is lower. Also, caudal-rostral asymmetry has been observed in lambda(//). Feasibility of using DTI to detect microstructural changes in chronic disease has been demonstrated. |
| Databáze: | OpenAIRE |
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