Effect of beta-adrenergic blockade with alprenolol on ST-segment depression and circulatory dynamics during exercise in patients with effort angina
| Autor: | P.I. Korner, Sandra D. Anderson, P. J. Rozea, L. Bernstein, I.K. Bailey, G. Nyberg |
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| Rok vydání: | 1976 |
| Předmět: |
Adult
Male Cardiac output Blood Pressure Coronary Disease Angina Pectoris Coronary artery disease Angina chemistry.chemical_compound Oxygen Consumption Heart Rate Heart rate medicine Humans Cardiac Output Alprenolol business.industry Hemodynamics Middle Aged medicine.disease Blood pressure chemistry Sprint Anesthesia cardiovascular system Exercise Test Arterial blood Cardiology and Cardiovascular Medicine business |
| Zdroj: | American heart journal. 92(4) |
| ISSN: | 0002-8703 |
| Popis: | Summary o 1.Nine subjects with severe coronary artery disease were studied during graded "sprint and "steady-state exercise before and after intravenous administration of the beta-receptor antagonist alprenolol. During "sprint workload was increased every minute until maximum work capacity (W max ) was reached. "Steady-state exercise was performed at work rates of 0.25, 0.50, and 0.75 of each subject's sprint W max . Variables measured included ST-segment depression, changes in heart rate, blood pressure, respiratory gas exchange, and arterial blood composition. Cardiac output (indirect Fick) was measured during "steady-state exercise. 2.Alprenolol did not alter W max during "sprint but reduced the incidence of angina in both types of exercise. After the drug work capacity was limited by symptoms and signs suggestive of mild left ventricular failure. 3.The relationship between workload (normalized in terms of W max ) and ST-segment depression was curvilinear. Under control conditions a given rate of work during "steady-state exercise was associated with more marked ST-segment depression than during "sprint. Alprenolol displaced the work-ST-depression curve to the right in each type of exercise; now a given rate of work produced similar ST-depression during "steady-state and "sprint exercise. 4.Alprenolol attenuated the exercise tachycardia during both types of exercise. Cardiac output was lower in "steady-state exercise after the drug than under control conditions. Metabolic effects included significant reduction in body oxygen consumption after alprenolol at 0.25 W max and diminished arterial lactate at 0.75 W max . The beneficial effects of the drug thus appeared to involve not only cardiac but peripheral effects on beta receptors. 5.Before alprenolol cardiac output was relatively fixed at all workloads, but after the drug there was a work-related rise in output in five out of nine subjects. Comparison with data in normal subjects suggested that in anginal subjects cardiac output at low "steady-state workloads was inappropriately high. |
| Databáze: | OpenAIRE |
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