Bowel ultrasound score is accurate in assessing response to therapy in patients with Crohn's disease
| Autor: | Gionata Fiorino, Cecilia Dell'Avalle, Federica Furfaro, Laurent Peyrin-Biroulet, Ferdinando D'Amico, Stefanos Bonovas, Silvio Danese, Vincenzo Craviotto, Mariangela Allocca, Alessandra Zilli |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Response to therapy Colonoscopy Gastroenterology Severity of Illness Index Lesion Crohn Disease Internal medicine medicine Humans Pharmacology (medical) In patient Prospective Studies Sensitivity to change Ultrasonography Crohn's disease Hepatology medicine.diagnostic_test business.industry Ultrasound medicine.disease Intestines medicine.symptom business After treatment |
| Zdroj: | Alimentary pharmacologytherapeuticsREFERENCES. 55(4) |
| ISSN: | 1365-2036 |
| Popis: | BACKGROUND We developed a non-invasive bowel ultrasound score (BUSS) to assess disease activity in Crohn's disease (CD). BUSS >3.52 is an indicator of endoscopic activity (SES-CD>2). AIM To assess whether BUSS, in addition to detecting inflammatory lesions, also detects relevant changes of these lesions over time. METHODS This was a prospective observational study of 49 patients with active CD. All patients underwent bowel ultrasound and colonoscopy at baseline and at re-assessment after treatment with biologics and/or immunosuppressants. The primary objective was to assess the sensitivity to change of BUSS in patients treated for active CD, using the SES-CD as reference standard. RESULTS BUSS changed significantly from baseline to re-assessment in patients achieving endoscopic response (a reduction of SES-CD of at least 50% vs baseline: 4.87 [3.78-6.0] vs 2.47 [2.25-3.36], P |
| Databáze: | OpenAIRE |
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