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Background: Primary aldosteronism (PA) has a reported prevalence of up to 30% in cases of resistant hypertension and is associated with worse cardiovascular outcomes than BP-matched essential hypertension (EH), but is substantially under-diagnosed due to the lack of specific symptoms and signs. Ambulatory blood pressure monitoring (ABPM) provides a non-invasive method for evaluating circadian BP variations, offers valuable prognostic information and may help to differentiate PA from EH in patients referred with non-specific hypertension for investigation. Aims: To compare AMBP parameters in hypertensive patients with established PA and those without, and correlate these parameters with cardiovascular outcomes. Methods: AMBP readings were evaluated retrospectively in 453 patients assessed at Monash Heart (the largest cardiology service in Victoria, Australia). Patient demographics, screening aldosterone and renin concentrations and medications were retrieved from medical records. 414 hypertensive patients with presumed EH and 39 PA patients were identified and their cardiovascular events (myocardial infarction, left ventricular hypertrophy, coronary artery disease, atrial fibrillation) were recorded. All parameters are reported as the median [interquartile range], unless stated otherwise. Statistical significance was set at p |
