Identification of peptide and protein doping related drug compounds confiscated in Denmark between 2007-2013
| Autor: | Kristian Linnet, Rune Andersen Hartvig, Lotte Ask Reitzel, Petur Weihe Dalsgaard, Irene Breum Müller, Niels Bjerre Holm |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Drug
chemistry.chemical_classification hormones K5000-5582 biology screening media_common.quotation_subject Peptide doping high-resolution ms proteins Criminal law and procedure Somatropin Social pathology. Social and public welfare. Criminology chemistry Biochemistry peptides biology.protein Trypsin Digestion black market drugs HV1-9960 mass spectrometry media_common Follistatin |
| Zdroj: | Hartvig, R A, Holm, N B, Dalsgaard, P W, Reitzel, L A, Müller, I B & Linnet, K 2014, ' Identification of peptide and protein doping related drug compounds confiscated in Denmark between 2007-2013 ', Scandinavian Journal of Forensic Science, vol. 20, no. 2, pp. 42-49 . https://doi.org/10.2478/sjfs-2014-0003 Scandinavian Journal of Forensic Science, Vol 20, Iss 2, Pp 42-49 (2014) |
| DOI: | 10.2478/sjfs-2014-0003 |
| Popis: | We present an overview of protein and peptide compounds confiscated in Denmark from late 2007 till late 2013 together with a description of a newly developed HRAM-LC-MS method used for identification. As examples of identification, we present data for the peptides AOD-9604, [D-Ala2, Gln8, Ala15, Leu27]sermorelin and the protein follistatin. It was found that a method with minimum sample preparation could be implemented for all of the confiscated peptides and the protein somatropin. However, for the protein follistatin it was necessary to include trypsin digestion in the sample preparation, which considerably increases the overall analysis time. |
| Databáze: | OpenAIRE |
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