DBSI server: DNA binding site identifier
| Autor: | Shravan Sukumar, Julie C. Mitchell, Spencer S. Ericksen, Xiaolei Zhu |
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| Rok vydání: | 2016 |
| Předmět: |
Models
Molecular 0301 basic medicine Statistics and Probability Support Vector Machine Protein Conformation Plasma protein binding Computational biology Biochemistry DNA-binding protein World Wide Web 03 medical and health sciences chemistry.chemical_compound Protein structure Binding site Molecular Biology Binding Sites Chemistry Proteins RNA DNA Computer Science Applications DNA-Binding Proteins Identifier DNA binding site Computational Mathematics 030104 developmental biology Computational Theory and Mathematics Protein Binding |
| Zdroj: | Bioinformatics. 32:2853-2855 |
| ISSN: | 1367-4811 1367-4803 |
| DOI: | 10.1093/bioinformatics/btw315 |
| Popis: | Summary: Protein–nucleic acid interactions are among the most important intermolecular interactions in the regulation of cellular events. Identifying residues involved in these interactions from protein structure alone is an important challenge. Here we introduce the webserver interface to DNA Binding Site Identifier (DBSI), a powerful structure-based SVM model for the prediction and visualization of DNA binding sites on protein structures. DBSI has been shown to be a top-performing model to predict DNA binding sites on the surface of a protein or peptide and shows promise in predicting RNA binding sites. Availability and Implementation: Server is available at http://dbsi.mitchell-lab.org Contact: jcmitchell@wisc.edu Supplementary information: Supplementary data are available at Bioinformatics online. |
| Databáze: | OpenAIRE |
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