Risks associated with cryopreservation: a survey of assisted conception units in the UK and Ireland

Autor:	Mathew Tomlinson, David Morroll
Rok vydání:	2008
Předmět:	Male Embryology Nitrogen MEDLINE Sample (statistics) Fertilization in Vitro Risk Assessment Specimen Handling Irish Surveys and Questionnaires Accidents Occupational Humans Medicine Risk management Cryopreservation business.industry Obstetrics and Gynecology General Medicine medicine.disease United Kingdom language.human_language Equipment failure Reproductive Medicine language Equipment Contamination Equipment Failure Female Medical emergency business Risk assessment Ireland Semen Preservation
Zdroj:	Human Fertility. 11:33-42
ISSN:	1742-8149 1464-7273
DOI:	10.1080/14647270701553280
Popis:	A number of recent, high-profile incidents involving loss or damage to cryopreserved material held in IVF units or sperm storage centres have highlighted the need for centres to carefully review their cryostorage practice and take action. Critical disasters involving lost or damaged patient material, although high profile, are still thought to be rare, and there has been concern that we should ensure that any response is proportionate to risk. However, as no regulators, manufacturers or similar professional disciplines have collected information in the long term, our knowledge of the true incidence of such adverse events is extremely poor. Recognizing the need for some solid data, the UK Association of Clinical Embryologists (ACE) conducted a survey on the subject, at its joint meeting with the Association of Irish Clinical Embryologists (ICE) (January, 2006). Questions were asked in relation to the risk of: injury to personnel; and potential loss of and potential damage to stored material. The number of serious and not so serious adverse events/situations relating to both staff and sample safety are discussed in detail. The incidence of problems was certainly higher than we had imagined; the lack of general training and awareness amongst our staff is a serious cause for concern, and appears to leave the industry vulnerable. Moreover, the survey highlighted the need for a coordinated approach to the collection of more detailed information both prospectively and retrospectively. Regulators, manufacturers, allied professional bodies and, more importantly, centres should be encouraged to share both recent and historic data relating to adverse events, in order that accurate risk assessments can be made in future.
Databáze:	OpenAIRE
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