Tuning the solubility of ionophores: glutathione-mediated transport of chloride ions across hydrophobic membranes
| Autor: | Debasis Manna, M. T. Shah, Nasim Akhtar, Nirmalya Pradhan, Sachin Kumar, Oindrila Biswas, Subhasis Dey, Vishnu Kumar, Abhishek Saha |
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| Rok vydání: | 2019 |
| Předmět: |
Aqueous solution
010405 organic chemistry Chemistry Sulfonium Metals and Alloys General Chemistry Glutathione 010402 general chemistry 01 natural sciences Combinatorial chemistry Chloride Catalysis 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound Mediated transport Materials Chemistry Ceramics and Composites medicine Solubility Lipid bilayer Cytotoxicity medicine.drug |
| Zdroj: | Chemical Communications. 55:8482-8485 |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | A stimuli-responsive anion transport strategy was successfully employed to regulate the water solubility of ionophores and promote controlled transport of Cl- ions across lipid bilayers. A sulfonium-based proanionophore was efficiently activated by glutathione to regenerate the active anionophore, which allowed controlled transport of Cl- ions in a cellular environment with lower cytotoxicity. |
| Databáze: | OpenAIRE |
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