Correlation between Plasma D-Dimer Level and Severity and Prognosis in Patients Admitted at Emergency Department with Trauma
| Autor: | Zheng-Ping An, Hang-Bin Huang, Zheng-Gang Wang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
030213 general clinical medicine Youden's J statistic General Biochemistry Genetics and Molecular Biology Fibrin Fibrinogen Degradation Products 03 medical and health sciences Young Adult 0302 clinical medicine Injury Severity Score D-dimer Medicine Humans Young adult Retrospective Studies Receiver operating characteristic business.industry Retrospective cohort study Emergency department Middle Aged Prognosis Standard error ROC Curve Anesthesia Wounds and Injuries business Emergency Service Hospital |
| Zdroj: | Clinical laboratory. 66(1) |
| ISSN: | 1433-6510 |
| Popis: | BACKGROUND To investigate the correlation between plasma D-dimer level and severity and prognosis of patients admitted to the emergency department with trauma. METHODS A total of 168 trauma patients admitted to the department of emergency surgery of Shengzhou People's Hospital were included in this study. The general information was collected, and the plasma D-dimer level was measured within 24 hours after admission. Patients were divided into the mild traumatic group (ISS ≤ 16 points), the moderate traumatic group (16 25 points) according to the Injury Severity Score (ISS) evaluation. According to the results from a 28-day follow-up, plasma D-dimer levels were compared between the survival group and the death group. The correlation between plasma D-dimer levels and severity of trauma patients admitted to the emergency department (according to the ISS) was analyzed. The receiver operating characteristic (ROC) curve evaluated the predictive value of plasma D-dimer levels for prognosis in patients admitted to the emergency department with trauma. RESULTS Plasma D-dimer levels successively increased from the mild traumatic group (2.51 ± 0.46 mg/L), the moderate traumatic group (4.09 ± 1.00 mg/L) to the severe traumatic group (6.58 ± 1.14 mg/L) (F = 0.659, p < 0.05). Plasma D-dimer levels were significantly and positively correlated with ISSs (r = 0.720, p < 0.001). The plasma D-dimer level in the survival group (3.72 ± 1.26 mg/L) was significantly lower than that in the death group (5.19 ± 0.87 mg/L) (t = 6.251, p < 0.001). According to the Youden index, the optimal cutoff value of plasma D-dimer was 4.00 mg/L, the AUC was 0.849, the standard error was 0.034, the 95% CI was 0.783 - 0.915, the sensitivity was 0.938, and the specificity was 0.603. CONCLUSIONS Plasma D-dimer levels were positively correlated with the severity of patients with trauma admitted to the department of emergency surgery and can predict poor prognosis. |
| Databáze: | OpenAIRE |
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