Magnetic force microscopy analysis of apoptosis of HL-60 cells induced by complex of antisense oligonucleotides and magnetic nanoparticles
| Autor: | De-hong Long, Xingyu Li, Hebai Shen, Nengqin Jia, Ya-ming Dong, Haiqing Zhou, Longzhang Zhu, Yang Sun, Xi Xin |
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| Rok vydání: | 2006 |
| Předmět: |
Biophysics
Direct morphology Nanoparticle Apoptosis HL-60 Cells Microscopy Scanning Probe Ferric Compounds Sensitivity and Specificity Biochemistry Magnetics chemistry.chemical_compound Leukemia Promyelocytic Acute Humans Organic Chemistry Tumor therapy Oligonucleotides Antisense Silicon Dioxide Molecular biology Nanostructures chemistry Antisense oligonucleotides Magnetic nanoparticles Magnetic force microscope Iron oxide nanoparticles |
| Zdroj: | Biophysical Chemistry. 122:1-4 |
| ISSN: | 0301-4622 |
| DOI: | 10.1016/j.bpc.2006.01.003 |
| Popis: | Magnetic force microscopy (MFM) has been employed to observe antisense oligonucleotides (ASOs)-coupled silica-coated magnetic iron oxide nanoparticles (SMNPs) internalized into human leukemia (HL-60) cells. The experiment demonstrated that the ASOs-coupled SMNPs delivery into the cells really occurred. The nanoparticles were internalized into the cells and the apoptotic topography can be directly visualized simultaneously with MFM technology. These present observations offer direct morphology evidence on studying the apoptosis of tumor cells and provide useful information for better design of new diagnostic and therapeutic tools in tumor treatment. |
| Databáze: | OpenAIRE |
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