Prostate-Specific Antigen fluctuation: what does it mean in diagnosis of prostate cancer?
| Autor: | Jin Woong Kim, Jun Seok Kim, Seung Il Jung, Kwangsung Park, Dong Deuk Kwon, Je-Guk Ryu, Eu Chang Hwang, Taek Won Kang |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Prostate biopsy Biopsy Urology lcsh:RC870-923 urologic and male genital diseases Risk Assessment Statistics Nonparametric Prostate cancer Reference Values Prostate Diagnosis Biomarkers Tumor medicine Humans In patient Aged Retrospective Studies Aged 80 and over medicine.diagnostic_test Receiver operating characteristic business.industry Age Factors Prostatic Neoplasms Retrospective cohort study Middle Aged Prostate-Specific Antigen lcsh:Diseases of the genitourinary system. Urology medicine.disease Surgery Prostate-specific antigen medicine.anatomical_structure ROC Curve Original Article business |
| Zdroj: | International braz j urol, Volume: 41, Issue: 2, Pages: 258-264, Published: APR 2015 International Brazilian Journal of Urology, Vol 41, Iss 2, Pp 258-264 (2015) International braz j urol v.41 n.2 2015 International Braz J Urol Sociedade Brasileira de Urologia (SBU) instacron:SBU International Brazilian Journal of Urology : official journal of the Brazilian Society of Urology |
| ISSN: | 1677-5538 |
| DOI: | 10.1590/s1677-5538.ibju.2015.02.11 |
| Popis: | Objective To investigate whether prostate-specific antigen (PSA) fluctuation correlates with a prostate cancer and to assess whether PSA fluctuation could be used for diagnosis of prostate cancer. Materials and Methods Our study included 229 patients who were performed a prostate biopsy (non-cancer group, 177; prostate cancer group, 52). Enrolled patients were provided twice PSA tests within 6 months. PSA fluctuation (%/month) was defined as a change rate of PSA per a month. Independent t test was used to compare between two groups. Receiver operator characteristic curve was used to assess the availability as a differential diagnostic tool and the correlation. Simple linear regression was performed to analyze a correlation between PSA fluctuation and other factors such as age, PSA, PSA density, and prostate volume. Results There were significant differences in PSA, PSA density, percentage of free PSA, and PSA fluctuation between two groups. PSA fluctuation was significantly greater in non-cancer group than prostate cancer group (19.95±23.34%/month vs 9.63±8.57%/month, P=0.004). The most optimal cut-off value of PSA fluctuation was defined as 8.48%/month (sensitivity, 61.6%; specificity, 59.6%; AUC, 0.633; P=0.004). In a simple linear regression model, only PSA level was significantly correlated with PSA fluctuation. Conclusion Patients with wide PSA fluctuations, although baseline PSA levels are high, might have a low risk of diagnosis with prostate cancer. Thus, serial PSA measurements could be an option in patients with an elevated PSA level. |
| Databáze: | OpenAIRE |
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