Expression and clinical significance of CD44V5 and CD44V6 in resectable colorectal cancer
| Autor: | José C. Fernández, Manuel García-Morán, Miguel Bongera, María D. Corte, García-Muñiz Jl, Allende Mt, Francisco J. Vizoso, Richard R. R. Gava |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Pathology Colorectal cancer Sensitivity and Specificity Gastroenterology Disease-Free Survival Flow cytometry Predictive Value of Tests Internal medicine Cell Adhesion Carcinoma Humans Medicine Clinical significance Prospective Studies Prospective cohort study Aged Glycoproteins Immunoassay Hematology biology medicine.diagnostic_test business.industry CD44 General Medicine Middle Aged Flow Cytometry Prognosis medicine.disease Hyaluronan Receptors Oncology Predictive value of tests Multivariate Analysis biology.protein Female Colorectal Neoplasms business |
| Zdroj: | Journal of Cancer Research and Clinical Oncology. 130:679-686 |
| ISSN: | 1432-1335 0171-5216 |
| Popis: | This study was conducted to evaluate the prognostic significance of CD44v5 and CD44v6 in resectable colorectal cancer. Membranous CD44v5 and CD44v6 levels were measured by an immunoenzymatic assay in tumors and surrounding mucosal samples obtained from 105 patients with resectable colorectal carcinomas. There were no significant differences of CD44v5 levels between tumors [median: 3.2 (range: 0.9–83.5) ng/mg protein) and surrounding mucosal samples (3 (3–146.2) ng/mg protein]. However, tumor samples showed significantly higher CD44v6 levels [19.5 (2.2–562.9) ng/mg protein] than mucosal samples [5 (5–230) ng/mg protein] (P=0.0001). Patients with higher CD44v5 or CD44v6 content in tumor samples had a considerably shorter relapse-free survival (P |
| Databáze: | OpenAIRE |
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