Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas
| Autor: | Alan Hubbard, Enrique Samper, Lucia Morgado, Antonio Bernad, Simon Melov, Juan Camilo Estrada, Susana Cadenas |
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| Rok vydání: | 2009 |
| Předmět: |
Mitochondrial DNA
Thymus Gland Biology Mitochondrion Lymphoma T-Cell medicine.disease_cause DNA Mitochondrial Biochemistry Article Proto-Oncogene Proteins c-myc Mice Oxygen Consumption Downregulation and upregulation Physiology (medical) Proton transport medicine Animals Glycolysis Mice Knockout Gene Expression Profiling Mitochondria Cell biology Mice Inbred C57BL Gene expression profiling Oxidative Stress Electron Transport Chain Complex Proteins Mitochondrial biogenesis Tumor Suppressor Protein p53 Carcinogenesis |
| Zdroj: | Free Radical Biology and Medicine. 46:387-396 |
| ISSN: | 0891-5849 |
| Popis: | Lymphomas adapt to their environment by undergoing a complex series of biochemical changes that are currently not well understood. To better define these changes, we examined the gene expression and gene ontology profiles of thymic lymphomas from a commonly used model of carcinogenesis, the p53(-/-) mouse. These tumors show a highly significant upregulation of mitochondrial biogenesis, mitochondrial protein translation, mtDNA copy number, reactive oxygen species, antioxidant defenses, proton transport, ATP synthesis, hypoxia response, and glycolysis, indicating a fundamental change in the bioenergetic profile of the transformed T cell. Our results suggest that T cell tumorigenesis involves a simultaneous upregulation of mitochondrial biogenesis, mitochondrial respiration, and glycolytic activity. These processes would allow cells to adapt to the stressful tumor environment by facilitating energy production and thereby promote tumor growth. Understanding these adaptations is likely to result in improved therapeutic strategies for this tumor type. |
| Databáze: | OpenAIRE |
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