Variation of corneal refractive index with hydration
| Autor: | Matthew R. Glucksberg, Young L. Kim, Thomas K. Goldstick, Joseph T. Walsh |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Materials science
Time Factors genetic structures Diagnostic Techniques Ophthalmological Corneal hydration Collagen fibril Corneal Diseases Cornea Optics Optical coherence tomography medicine Animals Radiology Nuclear Medicine and imaging Tomography Bovine cornea Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Epithelium Corneal Water Models Theoretical eye diseases Refractometry medicine.anatomical_structure Cattle sense organs Collagen business Refractive index Biomedical engineering |
| Zdroj: | Physics in medicine and biology. 49(5) |
| ISSN: | 0031-9155 |
| Popis: | We report the effect of changes in the corneal hydration on the refractive index of the cornea. Using optical coherence tomography (OCT), the geometrical thickness and the group refractive index of the bovine cornea were derived simultaneously as the corneal hydration was varied. The corneal hydration was then calculated from the corneal thickness. The group refractive index of the cornea increased non-linearly as the cornea dehydrated. In addition, a simple mathematical model was developed, based on the assumption that changes in corneal hydration occur only in the interfibrilar space with constant water content within the collagen fibrils. Good agreement between the experimental results and the mathematical model supports the assumption. The results also demonstrate that the measurement of refractive index is a quantitative indicator of corneal hydration. |
| Databáze: | OpenAIRE |
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