Serum Biochemistry of Lumpy Skin Disease Virus-Infected Cattle
| Autor: | Müge Doğan, Oguzhan Avci, Murat Şevik, Ömer Barış İnce |
|---|---|
| Přispěvatelé: | Selçuk Üniversitesi |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Article Subject 040301 veterinary sciences Lumpy Skin Disease lcsh:Medicine AutoAnalyzer General Biochemistry Genetics and Molecular Biology Capripoxvirus 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound Blood serum Lumpy skin disease Animals Medicine Aspartate Aminotransferases Renal Insufficiency Creatinine General Immunology and Microbiology biology business.industry lcsh:R Proteins 04 agricultural and veterinary sciences General Medicine Alkaline Phosphatase biology.organism_classification medicine.disease Lumpy skin disease virus Virology Blood proteins 030104 developmental biology chemistry Blood chemistry DNA Viral Immunology Cattle business Liver Failure Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2016 (2016) |
| ISSN: | 2314-6141 2314-6133 |
| DOI: | 10.1155/2016/6257984 |
| Popis: | WOS: 000376320600001 PubMed: 27294125 Lumpy skin disease is an economically important poxvirus disease of cattle. Vaccination is the main method of control but sporadic outbreaks have been reported in Turkey. This study was carried out to determine the changes in serum biochemical values of cattle naturally infected with lumpy skin disease virus (LSDV). For this study, blood samples in EDTA, serum samples, and nodular skin lesions were obtained from clinically infected animals (n = 15) whereas blood samples in EDTA and serum samples were collected from healthy animals (n = 15). A quantitative real-time PCR method was used to detect Capripoxvirus (CaPV) DNA in clinical samples. A real-time PCR high-resolution melt assay was performed to genotype CaPVs. Serum cardiac, hepatic, and renal damage markers and lipid metabolism products were measured by autoanalyzer. LSDV nucleic acid was detected in all samples which were obtained from clinically infected cattle. The results of serum biochemical analysis showed that aspartate aminotransferase, alkaline phosphatase, total protein, and creatinine concentrations were markedly increased in serum from infected animals. However, there were no significant differences in the other biochemical parameters evaluated. The results of the current study suggest that liver and kidney failures occur during LSDV infection. These findings may help in developing effective treatment strategies in LSDV infection. |
| Databáze: | OpenAIRE |
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