Semi-synthesis of antibacterial dialkylresorcinol derivatives
| Autor: | Jianye Li, Yue Shi, Benjamin R. Clark |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
2019-20 coronavirus outbreak 030106 microbiology Microbial Sensitivity Tests 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Derivative (finance) Drug Discovery Pseudomonas aurantiaca Organic chemistry Derivatization Alkyl Pharmacology chemistry.chemical_classification biology Strain (chemistry) Bacteria Molecular Structure 010405 organic chemistry Resorcinols biology.organism_classification Antimicrobial 0104 chemical sciences Anti-Bacterial Agents chemistry Mic values Drug Design |
| Zdroj: | The Journal of antibiotics. 74(1) |
| ISSN: | 1881-1469 |
| Popis: | Dialkylresorcinols are a class of antimicrobial natural products produced by a range of bacterial species. Semi-synthetic derivatization of two microbial dialkylresorcinols isolated from a Pseudomonas aurantiaca strain has yielded 21 derivatives, which were tested for antimicrobial activity, revealing several trends in their activity. The presence of aromatic and phenolic hydrogen atoms was crucial for activity, with all derivatives lacking these features possessing greatly reduced activity. On the other hand, derivatives with shorter alkyl chains at C-5 possessed lower MIC values, while one mono-fluorosulfated derivative showed significantly improved activity against several of the test strains. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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