Metastasizing neuroendocrine carcinoma of the larynx with calcitonin and somatostatin secretion and CEA production, resembling medullary thyroid carcinoma
| Autor: | Marie-Francoise Dehou, Willy Gepts, Robert Sacre, G. Somers, F. Warson, Gerda Smets, G. Storme, S. Van Belle, Günter Klöppel |
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| Rok vydání: | 1990 |
| Předmět: |
Calcitonin
Male endocrine system Pathology medicine.medical_specialty Skin Neoplasms endocrine system diseases Somatostatin secretion Enolase Pathology and Forensic Medicine Metastasis Diagnosis Differential Thyroid carcinoma Carcinoma Humans Medicine Thyroid Neoplasms Laryngeal Neoplasms neoplasms Molecular Biology Epithelioma Brain Neoplasms business.industry Cell Biology General Medicine Middle Aged medicine.disease Neurosecretory Systems digestive system diseases Carcinoembryonic Antigen Somatostatin Lymphatic Metastasis business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Virchows Archiv A Pathological Anatomy and Histopathology. 416:539-543 |
| ISSN: | 1432-2307 0174-7398 |
| Popis: | A 55-year-old man presented with a metastasizing moderately differentiated neuroendocrine carcinoma of the larynx (atypical carcinoid). Immunocytochemical demonstration of neuroendocrine markers (neuron-specific enolase and chromogranin-A) and presence of membrane-bound neurosecretory granules in the cells established the neuroendocrine nature of the tumour. In addition, the tumour was found to produce calcitonin, somatostatin and carcino-embryonic antigen (CEA). Calcitonin and somatostatin were also secreted. On the basis of this particular marker constellation the tumour closely resembles medullary thyroid carcinoma. Review of the recent literature on carcinoids of the larynx reveals immunoreactivity for calcitonin and CEA in a high percentage of cases. |
| Databáze: | OpenAIRE |
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