Preliminary Trial of Rebamipide for Prevention of Low-Dose Aspirin-Induced Gastric Injury in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Study
| Autor: | Mototsugu Kato, Go Kamada, Masahiro Asaka, Aki Imai, Yuichi Shimizu, Jyojyo Hirota, Yuji Ono, Hiroshi Takeda, Manabu Nakagawa, Kikuko Takagi, Souichi Nakagawa, Shouko Ono, Tamotsu Hata, Takeshi Yoshida |
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| Rok vydání: | 2009 |
| Předmět: |
low-dose aspirin
medicine.medical_specialty Aspirin Nutrition and Dietetics Erythema business.industry Clinical Biochemistry Fornix Medicine (miscellaneous) healthy subject rebamipide Placebo Gastroenterology Crossover study Surgery prevention Internal medicine medicine Rebamipide Original Article Gastric injury medicine.symptom business Antrum medicine.drug |
| Zdroj: | Journal of Clinical Biochemistry and Nutrition |
| ISSN: | 1880-5086 0912-0009 |
| DOI: | 10.3164/jcbn.09-24 |
| Popis: | Although low-dose aspirin is widely used, since it is a cheap and effective means of prevention of cardiovascular events, it can cause hemorrhagic gastrointestinal complications. The aim of this study was to evaluate the efficacy of rebamipide in preventing low-dose aspirin-induced gastric injury. A randomized, double-blind, placebo-controlled, crossover trial was performed in twenty healthy volunteers. Aspirin 81 mg was administered with placebo or rebamipide 300 mg three times daily for 7 consecutive days. The rebamipide group exhibited significant prevention of erythema in the antrum compared with the placebo group (p = 0.0393, respectively). Results for the body and fornix did not differ significantly between the placebo and rebamipide groups. In conclusion, short-term administration of low-dose aspirin induced slight gastric mucosal injury in the antrum, but not in the body or fornix. Rebamipide may be useful for preventing low-dose aspirin-induced gastric mucosal injury, especially which confined to the antrum. |
| Databáze: | OpenAIRE |
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