The IDO genetic polymorphisms and postpartum depressive symptoms: an association study in Chinese parturients who underwent cesarean section
| Autor: | Kai-Ming Duan, Zhao-Qian Liu, Mi Yang, Jia-Hui Ma, Zhen-Dong Huang, He-Ya Yu, Xi Li, Ji-Ye Yin, Sai-Ying Wang, Hong-Hao Zhou, Ying-Yong Zhou |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty China Kynurenine pathway Genotype Single-nucleotide polymorphism Gastroenterology Polymorphism Single Nucleotide Pathogenesis Depression Postpartum 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Asian People Polymorphism (computer science) Pregnancy Internal medicine medicine Humans Indoleamine-Pyrrole 2 3 -Dioxygenase Kynurenine business.industry Cesarean Section Incidence (epidemiology) Tryptophan food and beverages Obstetrics and Gynecology 030227 psychiatry Psychiatry and Mental health chemistry Edinburgh Postnatal Depression Scale Case-Control Studies Female business 030217 neurology & neurosurgery |
| Zdroj: | Archives of women's mental health. 22(3) |
| ISSN: | 1435-1102 |
| Popis: | Postpartum depressive symptoms (PDS) are not an uncommon mood disorder in postpartum women. Our previous research indicated a role for increased tryptophan (TRP) metabolism along the kynurenine pathway (KP) in the pathogenesis of PDS. Accordingly, this study was going to investigate the association of indoleamine-2,3-dioxygenase (IDO, a key enzyme of KP) genetic polymorphisms with PDS. Seven hundred twenty-five women receiving cesarean section were enrolled in this study. PDS was determined by an Edinburgh Postnatal Depression Scale (EPDS) score ≥ 13. Subsequently, 48 parturients with PDS and 48 parturients without PDS were selected for investigation of perinatal serum concentrations of TRP, kynurenine (KYN), and KYN/TRP ratio, the latter is the representative of IDO activity. In addition, seven single nucleotide polymorphisms of the IDO gene were examined. Following this genotyping, 50 parturients carrying the IDO rs10108662 AA genotype and 50 parturients carrying the IDO rs10108662 AC + CC genotype were selected for comparisons of TRP, KYN, and KYN/TRP ratio levels. This study showed the PDS incidence of 6.9% in the Chinese population, with PDS characterized by increased IDO activity (p |
| Databáze: | OpenAIRE |
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