Rational modulation of coumarin–hemicyanine platform based on OH substitution for higher selective detection of hypochlorite
| Autor: | Tong Zhang, Li Liu, Rui-Feng Zeng, Yan-Hong Qin, Yun Liu, Xiao-Yi Jiang, Yue Ding, Ayinazhaer Aihemaiti, Jin-Shuai Lan, Rodney J. Y. Ho |
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| Rok vydání: | 2020 |
| Předmět: |
Indoles
Hypochlorite Carrageenan Photochemistry Catalysis Mice chemistry.chemical_compound Coumarins Limit of Detection In vivo Materials Chemistry Animals Humans Moiety Zebrafish Rapid response Fluorescent Dyes Detection limit Microscopy Confocal Chemistry Arthritis Metals and Alloys Hep G2 Cells General Chemistry Coumarin Ratiometric fluorescence Hypochlorous Acid Mitochondria Surfaces Coatings and Films Electronic Optical and Magnetic Materials RAW 264.7 Cells Spectrometry Fluorescence Microscopy Fluorescence Ceramics and Composites Selectivity |
| Zdroj: | Chemical Communications. 56:1219-1222 |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | To monitor delicate changes of biological HOCl in vivo, a new probe (OH-substituted coumarin-hemicyanine, probe 2) was synthesized for NIR and ratiometric HOCl detection. Selectivity studies indicated that the electron-donating group (OH) substituted on the indolium moiety enhanced the selectivity to detect HOCl. With HOCl, the probe showed a ratiometric fluorescence (I500/I650) with a low detection limit (49.1 nM) and a rapid response (within 2 min). In addition, probe 2 was successfully applied to visualize exogenous and endogenous HOCl in living cells and animals and exhibited a perfect mitochondria target ability. This probe has been further studied as a potential and powerful tool to probe HOCl in arthritis models. |
| Databáze: | OpenAIRE |
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