Effects of autologous adipose-derived regenerative stem cells administered at the time of anterior cruciate ligament reconstruction on knee function and graft healing
| Autor: | Jordi Català, Eduard Alentorn-Geli, Ramón Cugat, Jordi Navarro, Patricia Laiz, Pedro Álvarez-Díaz, Adrian Martinez-De la Torre, Betina Nishishinya, Xavier Cuscó, Roberto Seijas, José Maria Serra-Renom, David Barastegui, Gilbert Steinbacher, Montserrat García-Balletbó |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Knee Joint Graft healing Anterior cruciate ligament reconstruction medicine.medical_treatment Adipose-derived regenerative stem cells Adipose tissue Stem cells Bone-Patellar Tendon-Bone Grafting 0302 clinical medicine lcsh:Orthopedic surgery Medicine Graft maturation 030222 orthopedics Injertos óseos Middle Aged ACL reconstruction musculoskeletal system Treatment Outcome medicine.anatomical_structure Knee -- Surgery Female Ossos -- Empelts Rodillas -- Cirugía Stem cell Cèl·lules mare Adult Knee function Tejido adiposo medicine.medical_specialty Adolescent Ferides i lesions Células madre Anterior cruciate ligament Sports injuries Transplantation Autologous Young Adult 03 medical and health sciences Humans Wound Healing business.industry Anterior Cruciate Ligament Injuries Wounds and injuries Recovery of Function 030229 sport sciences Esports -- Lesions Surgery Teixit adipós Bone -- Grafts lcsh:RD701-811 Genolls -- Cirurgia business Heridas y lesiones human activities Deportes -- Heridas y lesiones Stem Cell Transplantation |
| Zdroj: | Journal of Orthopaedic Surgery, Vol 27 (2019) Recercat. Dipósit de la Recerca de Catalunya instname Journal of Orthopaedic Surgery, 27 (3) Recercat: Dipósit de la Recerca de Catalunya Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| ISSN: | 2309-4990 |
| Popis: | Purpose: To compare the healing and clinical outcomes of anterior cruciate ligament (ACL) reconstruction between patients with or without intraoperative administration of adipose-derived regenerative stem cells (ADRC). Methods: Between 2013 and 2014, the outcomes of 20 soccer players undergoing ACL reconstruction using bone–patellar tendon–bone autograft infiltrated with ADRC at the end of the procedure were compared to a historical, matched cohort of 19 soccer players undergoing the same procedure without ADRC. Outcomes were obtained at baseline, and 6 and 12 months postop for IKDC (International Knee Documentation Committee), Lysholm, and Lequesne, and at 2, 4, 6, and 12 months postop for VAS (visual analogue scale) for pain and graft maturation to evaluate the ligamentization process (magnetic resonance imaging (MRI)-based). Results: Both groups significantly improved the IKDC (p < 0.001 in both groups), Lysholm (p < 0.001 in both groups), Lequesne index (p < 0.001 in both groups), VAS for pain (p = 0.002 for the ADRC and p < 0.001 for the control group), and MRI scores (p < 0.001 in both groups) in the 12 months postop compared to baseline scores. However, there were no significant differences in the improvement of the outcomes between groups across time (p > 0.05). All patients returned to sports after surgery, but 8 (40%) patients in the ADRC and 13 (68.4%) patients in the control group had lower Tegner activity score at 12 months postop. Conclusions: Patients receiving ADRC at the time of ACL reconstruction significantly improved knee function and healing/maturation of the graft at 12 months. However, this improvement was not statistically significant compared to a control group undergoing ACL reconstruction alone. Journal of Orthopaedic Surgery, 27 (3) |
| Databáze: | OpenAIRE |
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