Pancreatic Stellate Cells Activation and Matrix Metallopeptidase 2 Expression Correlate With Lymph Node Metastasis in Pancreatic Carcinoma
| Autor: | Yao Wang, Tao Song, Zhen Chen, Juyuan Zhang, Yueguang Li, Ximo Wang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male MMP2 Pancreatic stellate cell 030204 cardiovascular system & hematology Desmin Metastasis 03 medical and health sciences 0302 clinical medicine Pancreatic cancer Humans Medicine 030212 general & internal medicine Pancreas Lymph node Aged biology business.industry Pancreatic Stellate Cells General Medicine Middle Aged medicine.disease Actins Pancreatic Neoplasms medicine.anatomical_structure Lymphatic Metastasis biology.protein Hepatic stellate cell Cancer research Matrix Metalloproteinase 2 Immunohistochemistry Female ACTA2 business |
| Zdroj: | The American Journal of the Medical Sciences. 357:16-22 |
| ISSN: | 0002-9629 |
| DOI: | 10.1016/j.amjms.2018.10.001 |
| Popis: | This study aimed to investigate the correlation between pancreatic stellate cell activation, matrix metallopeptidase 2 (MMP2) expression and lymph node metastasis in pancreatic carcinoma.Alpha-smooth muscle actin (ACTA2), Desmin (DES) and MMP2 were detected in 40 pancreatic carcinoma patients and 10 cases of normal pancreas tissues using immunohistochemistry. Then MMP2 and ACTA2 expression profiles in pancreatic cancer were obtained from UCSC (University of California, Santa Cruz) and SurvExpress.A total of 67.5% and 55.0% of cases positively expressed ACTA2 and DES in pancreatic carcinoma, respectively. MMP2 in pancreatic carcinoma was expressed in 55.0% of cases, and there were significant differences between the lymph node metastasis group and the lymph node nonmetastasis group, as well as invasion and noninvasion to the peripheral tissue group (P0.01). High throughput sequencing databases verified that ACTA2 and MMP2 gene expression were both upregulated in pancreatic carcinoma tissues.The coexpression of ACTA2 and DES was related to the expression of MMP2, and positively correlated with lymph node metastasis. Activation of pancreatic stellate cells may promote the expression of MMP2 and enhance the invasion and metastasis of pancreatic carcinoma. |
| Databáze: | OpenAIRE |
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