Acute Hematotoxicity of Oral Benzo(a)pyrene: The Role of the Ah Locus
| Autor: | V. Anselstetter, H. Heimpel |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
medicine.medical_specialty
animal structures Ratón Thymus Gland Biology complex mixtures Mice chemistry.chemical_compound Bone Marrow Oral administration Internal medicine Benzo(a)pyrene polycyclic compounds medicine Animals Erythropoiesis Lymphocytes Carcinogen Organ Size Hematology General Medicine Hematopoietic Stem Cells Hematopoiesis stomatognathic diseases Haematopoiesis Endocrinology medicine.anatomical_structure chemistry embryonic structures Toxicity Pyrene Female Aryl Hydrocarbon Hydroxylases Bone marrow Megakaryocytes Spleen Granulocytes |
| Zdroj: | Acta Haematologica. 76:217-223 |
| ISSN: | 1421-9662 0001-5792 |
| DOI: | 10.1159/000206059 |
| Popis: | Our results show a marked acute hematotoxicity of oral benzo(a)pyrene (BaP) in D2 mice as well as the extreme resistance of BDF1 individuals to bone marrow toxicity induced by oral BaP. Continued oral BaP produced severe bone marrow depression in D2 mice affecting all myelopoietic lineages, but produced only moderate bone marrow depression in BDF1 mice affecting erythropoiesis only. Pluripotent hematopoietic stem cells were almost completely destroyed in D2 individuals, but only reduced to approximately 40% in BDF1 individuals after 7 days of BaP. D2 mice were killed by 13 days of continued oral BaP, but BDF1 mice were still alive and in good condition even after 19 days of continued oral BaP. Analysis of the bone marrow and peripheral blood changes showed that severe toxic chemical bone marrow depression in D2 mice by continued oral BaP cannot serve as an experimental model system of acute aplastic anemia. |
| Databáze: | OpenAIRE |
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