REGULATION OF MICROORGANISMS SENSITIVITY TO ANTAGONISTIC ACTIVE REPRESENTATIVES OF MUTUALISTICALLY MICROFLORA BY THE ANTIMICROBIAL PEPTIDES
| Autor: | Yu. I. Peshkova, O L Kartashova, A. V. Andreeva, M. V. Sycheva |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification biology platelets of chicken Microorganism 030106 microbiology Antimicrobial peptides Medicine (miscellaneous) Peptide General Medicine Colonisation resistance biology.organism_classification Microbiology antagonism QR1-502 antimicrobial peptides 03 medical and health sciences 030104 developmental biology Biochemistry Enterococcus chemistry colonization resistance Antagonism Incubation Bacteria |
| Zdroj: | Журнал микробиологии, эпидемиологии и иммунобиологии, Vol 0, Iss 6, Pp 21-25 (2017) |
| ISSN: | 2686-7613 0372-9311 |
| DOI: | 10.36233/0372-9311-2017-6-21-25 |
| Popis: | Aim. Study of the effect of antimicrobial peptides (AMP) on the sensitivity of the conditional pathogenic of bacteria to the action of antagonistic active of representatives mutualistically microflora. Materials and methods. The study used peptides from platelets of chicken obtained by the method of reversed-phase high-performance liquid chromatography in stepwise and linear gradients of increasing concentrations of organic solvent. The effect of AMP on the sensitivity of microorganisms to antagonistic active substances of the dominant bacteria of the genus Lactobacillus, and Enterococcus were investigated in a joint incubation. Antagonistic activity of bacteria studied the gup method. Results. Shown an increased expression of antagonistic activity of indigenous microflora in relation to associative microflora after concubinage with a peptide fractions from platelets of chicken. Conclusion. The obtained results allow to assume the existence of new mechanisms of formation of the colonization resistance of the biotope. |
| Databáze: | OpenAIRE |
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